In our total project portfolio, we currently have six projects: five drug candidates and a product series in cosmetic dermatology. What the projects have in common is that they are based on two unique validated technology platforms that are based on solid research and collaborations with pioneering and internationally recognized researchers and academics.

Our unique, validated technology platforms

The cPLA2α technology

The cPLA2α technology consists of a series of proprietary small molecule inhibitors of the cytosolic phospholipase A2 (cPLA2α) enzyme involved in inflammation and uncontrolled cell growth. This provides a range of potentially attractive indications for the patented molecular inhibitors of cPLA2α including skin, cancer, liver and kidney diseases.

The technology comes primarily from the Norwegian University of Science and Technology (NTNU).

The development projects of the portfolio companies Avexxin Oncology AS and Reccura Therapeutics AS are based on this technology.

The FOL peptide technology

The FOL peptide technology consists of a series of patented tissue-protective peptides ("small proteins") that are based on a modified part of the natural human protein osteopontin. Osteopontin is a glycoprotein expressed in many types of tissues, including the hair follicle and bone, and plays a key role in cell stimulation processes.

The technology comes primarily from Lund University in Sweden.

The development projects of the portfolio company Follicum AB are based on this technology.

Our pipeline for drug candidates

Project
AVX001 GEL
Indication
Actinic keratosis
Modality
Topical
Company
Research
Preclinical
Phase I
Phase IIa
Phase IIb
Project
AVX001 GEL
Indication
Basal cell carcinoma
Modality
Topical
Company
Research
Preclinical
Phase I
Phase IIa
Phase IIb
Project
AVX420
Indication
Leukemia
Modality
Biological
Company
Research
Preclinical
Phase I
Phase IIa
Phase IIb
Project
FOL026
Indication
Prevention of cardiovascular complications in diabetes
Modality
Topical
Company
Research
Preclinical
Phase I
Phase IIa
Phase IIb
Project
AVX420/FOL026
Indication
Kidney and liver fibrosis
Modality
Biological
Company
Research
Preclinical
Phase I
Phase IIa
Phase IIb

Our pipeline for dermacosmetic products

Project
FOL005
Indication
Stimulation of hair growth
Modality
Topical
Company
Research
Development
Registration

Read more about our projects

FOL005

Stimulation of hair growth

FOL005 is a peptide based on a modified part of the endogenous osteopontin, a glycoprotein expressed by many tissues.FOL005 has shown to be a potent and safe drug candidate for stimulation of hair growth.

Read more on follicum.com

AVX001 Gel

Actinic keratosis

AVX001 is one of our drug candidates built on the cPLA2α platform. It is an inhibitor for topical administration that we are developing for the indications actinic keratosis (AK) and basal cell carcinoma (BCC). AVX001 has shown "Proof of concept" in our latest phase lla study for AK.

Read more on reccuratherapeutics.com

AVX420

Leukemia

AVX420 has a documented strong cPLA2α inhibitory effect in leukemia and triple-negative breast cancer, which shows that AVX420 may be a promising drug candidate for treatment of several types of cancer.

Read more on avexxinoncology.com

AVX420/FOL026

Kidney and liver fibrosis

AVX420 and FOL026 have proven their therapeutic potential for the treatment of fibrosis, for example in chronic kidney disease or liver disease.

FOL026

Prevention of cardiovascular complications in diabetes

FOL026 is a peptide-based drug candidate with novel and promising properties as potential innovative therapies in cardiovascular disease associated with diabetes.